Manufacturers and clinical laboratories are doing a reasonably good job assessing endogenous interferents that may alter lab test results. The next big hurdle is the assessment of interference from common drugs. There are literally hundreds of drugs in clinical use, both prescription and over-the-counter, which can vary widely in their blood and urine concentrations and which can introduce errors in laboratory testing. Which are the most important to test? An expert panel was convened to make specific recommendations concerning the drugs and concentrations that should be assessed when validating laboratory tests.
Sun Diagnostics simplifies interference testing with the ASSURANCE™ product line. ASSURANCE™ Interference Test Kits have been specifically designed with laboratories and manufacturers in mind. The interferents are high quality, highly concentrated materials from human sources (where possible) or purified chemicals. Recommended procedures and data analysis tools are also available.
Preparing concentrated drug solutions for interference testing has been labor intensive and expensive ̶ until now. Sun Diagnostics now offers Interference Test Solutions for Laboratory Use as part of interference testing procedures. Interferents available include: ACETAMINOPHEN, N-ACETYLCYSTEINE, ACETYLSALICYLIC ACID, AMPICILLIN SODIUM, CEFOXITIN SODIUM, CYCLOSPORINE, DOXYCYCLINE HCL, HEPARIN, IBUPROFEN, LEVODOPA, METHYLDOPA, METRONIDAZOLE, PHENYLBUTAZONE, RIFAMPICIN, and THEOPHYLLINE. Components may be purchased individually, in customer-defined combinations, or as INT-04 (one vial of each component).
Interference occurs when an endogenous or exogenous substance alters an assay result. Manufacturers are required to perform interference testing during assay development. Laboratories may choose to verify these claims as part of Good Laboratory Practice or while investigating questionable results.
Sun Diagnostics simplifies interference testing with the ASSURANCE™ product line. ASSURANCE™ Interference Test Kits have been specifically designed with laboratories and manufacturers in mind. The interferents are high quality, highly concentrated materials from human sources (where possible) or purified chemicals. Recommended procedures and data analysis tools are also available. Interferents are available as kit or individual vials to best match users’ needs.
Sun Diagnostics offers ASSURANCE™ Interference Test Kit Solutions for:
- INT-01 Routine Interferents
Contains: Triglyceride-rich lipoproteins, hemolysate, protein, conjugated bilirubin, and unconjugated bilirubin. INT-01 $800
- INT-02 HAMA
Contains: 5 different HAMA positive serum samples. $850
- INT-03 RF
Contains: 5 different RF positive plasma samples at high concentrations. $600
- INT-04 Drug Interferents
Contains: acetylcysteine, ampicillin Na, cefoxitin Na, doxycycline HCl, theophylline, levodopa, methyldopa, metronidazole, acetylsalicylic acid, ibuprofen, phenylbutazone, rifampicin, cyclosporine, acetaminophen and heparin. INT-04 $1100
- INT-06 Endogenous Interferents
Contains: creatinine, glucose, glycerol, lactate, pyruvate, urea, and uric acid. INT-06 $600
- INT-09 Additional Interferents
- Custom Interferents – Please contact us regarding your custom interferents needs.