by Rae | Feb 27, 2020 | Blog
CLSI teaches us that it is important to know the difference between a “true” quantity of a substance and an individual measurement result. In other words, we need to know both the limit of the blank (LoB) and the limit of detection (LoD) [CLSI. Protocols for...
by Rae | Feb 3, 2020 | Blog
Reports of biotin interference with laboratory tests are alarming. Biotin binds to streptavidin with high affinity, making the biotin-streptavidin system useful for immunoassays; however, elevated concentrations of biotin can interfere. In competitive assays,...
by Rae | Dec 6, 2019 | Blog
You have likely read method performance information with an arbitrary acceptance criterion e.g. plus or minus 10%. This is unfortunate because different measurands differ in the magnitude of error that impacts clinical decision making. Troponin, for example, needs to...
by Rae | Dec 4, 2019 | Blog
The Clinical and Laboratory Standards Institute (CLSI) has made valuable recommendations for interference testing in document EP07. We created Excel spreadsheets, designed specifically to follow CLSI recommendations and to help simplify the process. The cells...
by Rae | Nov 12, 2019 | Blog
Clinical Laboratory Standards Institute (CLSI) provides important guidance for interference testing.1 Many laboratorians find the CLSI document difficult to follow, which is why we have developed simple instructions and Excel Interference Worksheets to make...
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